My only quibble with https://loadaverage.org/url/6141812 is there is no way Cincinnati is great plains. Anyone that has ever been to Cincy knows it's not a plain.

Probably Appalachia, The South, Great Lakes, and The Plains all need to meet at Cincy.

I've never done anything by drive through Columbus, but...does Columbus being in Great Lakes make sense to people. It seems ok to me.